In Reason (DAW) you have to add it as a "multi channel control keyboard" for all its knobs and knobs to work, but there is no way to use the "two layers" of controls like in Ableton Live. Otherwise, it works fine with Ableton Live 11. With both software you can use more than one MidiMix at the same time without any problem, at least in my case. But one MidiMix is ​​never enough to have full control. I'm not advertising AkaiPro, I don't get paid a cent, but honestly a SetUp of two MidiMix and two APC minis (which I also have) would give you convenience and control over the software mix at a reasonable price.